Unraveling the photophysical characteristics and biological applications of vinyl sulfones as viscosity sensors.

ABSTRACT: For the first time, a series of vinyl sulfone-NH₂-based push-pull fluorophores (4a-4d) were introduced for their potential use in biological applications. The fluorophores 4a-4d were readily synthesized upon reduction of the corresponding vinyl sulfones-NO₂ (3a-3d), which were prepared by sulfonylation of nitrostyrene. Both types of probes can be prepared in high yields through a few steps with minimal cost. In diverse solvents, probes 4a-4d exhibited fluorescence with strong emission peaking around 403-490 nm. Additionally, the fluorescence intensity of probe 4d rose approximately 85-fold with increasing viscosity. The probes 4a-4d demonstrated good stability and photostability in a broad pH range. Moreover, probes 4a-4d showed significantly improved biocompatibility

SUBMITTER: Khaikate O 

PROVIDER: S-EPMC10236534 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature