MED27 plays a tumor-promoting role in breast cancer progression by targeting KLF4.

ABSTRACT: The mediator complex usually cooperates with transcription factors to be involved in RNA polymerase II-mediated gene transcription. As one component of this complex, MED27 has been reported in our previous studies to promote thyroid cancer and melanoma progression. However, the precise function of MED27 in breast cancer development remains poorly understood. Here, we found that MED27 was more highly expressed in breast cancer samples than in normal tissues, especially in triple-negative breast cancer, and its expression level was elevated with the increase in pathological stage. MED27 knockdown in triple-negative breast cancer cells inhibited cancer cell metastasis and stemness maintenance, which was accompanied by downregulation of the expression of EMT- and stem traits-associated protein

SUBMITTER: Wang R 

PROVIDER: S-EPMC10236612 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature