Effects of the factor Xa inhibitor rivaroxaban on the differentiation of endothelial progenitor cells.

ABSTRACT:

Background

We evaluated the efficacy of the factor Xa inhibitor rivaroxaban on the differentiation ability of vascular endothelial progenitor cells (EPCs), which play roles in vascular injury repair and atherogenesis. Antithrombotic treatment in patients with atrial fibrillation undergoing percutaneous coronary intervention (PCI) is challenging, and current guidelines recommend oral anticoagulant monotherapy 1 year or more after PCI. However, biological evidence of the pharmacological effects of anticoagulants is insufficient.

Methods

EPC colony-forming assays were performed using peripheral blood-derived CD34-positive cells from healthy volunteers. Adhesion and tube formation of cultured EPCs were assessed in human umbilical cord-derived CD34-positive cells. Endothelial cel

SUBMITTER: Sohma R 

PROVIDER: S-EPMC10236699 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature