The choroid plexus acts as an immune cell reservoir and brain entry site in experimental autoimmune encephalomyelitis.

ABSTRACT: The choroid plexus (ChP) has been suggested as an alternative central nervous system (CNS) entry site for CCR6⁺ Th17 cells during the initiation of experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis (MS). To advance our understanding of the importance of the ChP in orchestrating CNS immune cell entry during neuroinflammation, we here directly compared the accumulation of CD45⁺ immune cell subsets in the ChP, the brain and spinal cord at different stages of EAE by flow cytometry. We found that the ChP harbors high numbers of CD45^int resident innate but also of CD45^hi adaptive immune cell subsets including CCR6⁺ Th17 cells. With the exception to tissue-resident myeloid cells and B cells, numbers of CD

SUBMITTER: Lazarevic I 

PROVIDER: S-EPMC10236715 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature