Type 2 diabetes mellitus plays a protective role against osteoporosis --mendelian randomization analysis.

ABSTRACT:

Background

Type 2 diabetes mellitus (DM2) and osteoporosis (OP) are currently the two most significant causes of mortality and morbidity in older adults, according to clinical evidence. The intrinsic link between them is yet unknown, despite reports of their coexistence. By utilizing the two-sample Mendelian randomization (MR) approach, we sought to evaluate the causal impact of DM2 on OP.

Methods

The aggregate data of the whole gene-wide association study (GWAS) were analyzed. A two-sample MR analysis was performed using single-nucleotide polymorphisms (SNPs), which are strongly associated with DM2, as instrumental variables (IVs) to evaluate the causal analysis of DM2 on OP risk with OR values, using inverse variance weighting, MR-egger regression, and weighted median meth

SUBMITTER: Cheng L 

PROVIDER: S-EPMC10236750 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature