The effects of sildenafil citrate on intrauterine growth restriction: a systematic review and meta-analysis.

ABSTRACT:

Background

An increase in vascular resistance of uterine vessels is associated with intrauterine growth restriction (IUGR). Sildenafil citrate, a phosphodiesterase-5 inhibitor that stabilizes cyclic guanosine monophosphate (cGMP) and increases nitric oxide levels, improves placental perfusion by dilation of spiral arteries and is beneficial in managing IUGR. This study aims to determine the effectiveness of sildenafil citrate in improving perinatal outcomes in IUGR pregnancies.

Methods

Meta-analysis was performed on data extracted from all studies specific to sildenafil citrate in IUGR management, searching relevant articles on PubMed, Medline, Google Scholar, Embase, and Cochrane databases. Publications identified by the manual search, based on references in reviews, were a

SUBMITTER: Rakhanova Y 

PROVIDER: S-EPMC10236759 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature