Early Effect of Transcatheter Mitral Valve Repair on Cardiac Sympathetic Nerve Activity

ABSTRACT:

Background

Cardiac sympathetic nerve activity (SNA) is overactivated in heart failure patients and associated with clinical outcomes. The aim of this study is to investigate the early effect of MitraClip repair on cardiac SNA.

Methods

We evaluated the change of cardiac SNA by 123I- meta-iodobenzylguanidine (MIBG) scintigraphy in patients who underwent MitraClip repair from March 2019 to June 2020 in our hospital. Patients without acute procedural success were excluded, including patients who died or underwent mitral valve surgery before discharge. MIBG scintigraphy was performed at baseline and 1 ​month after MitraClip repair.

Results

We analyzed 48 patients (mean age 78.6 ± 10 years; 52.1% male; 37 secondary mitral regurgitation [SMR]/11 primary mitral regurgita

SUBMITTER:  

PROVIDER: S-EPMC10236802 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature