Antiviral effect of SARS-CoV-2 N-specific CD8⁺ T cells induced in lungs by engineered extracellular vesicles.

ABSTRACT: Induction of effective immunity in the lungs should be a requisite for any vaccine designed to control the severe pathogenic effects generated by respiratory infectious agents. We recently provided evidence that the generation of endogenous extracellular vesicles (EVs) engineered for the incorporation of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)-2 Nucleocapsid (N) protein induced immunity in the lungs of K18-hACE2 transgenic mice, which then can survive the lethal virus infection. However, nothing is known about the ability of the N-specific CD8⁺ T cell immunity in controlling viral replication in the lungs, a major pathogenic signature of severe disease in humans. To fill the gap, we investigated the immunity generated in the lungs by N-engineered EVs in terms of

SUBMITTER: Manfredi F 

PROVIDER: S-EPMC10237059 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature