Association of vitamin D and polymorphisms of its receptor with antiviral therapy in pregnant women with hepatitis B.

ABSTRACT:

Background

The interruption of mother-to-child transmission (MTCT) is considered important to decrease the individual and population morbidity of hepatitis B virus (HBV) infection as well as the global burden of hepatitis B. Serum vitamin D (VD) is associated with hepatitis B.

Aim

To assess whether baseline VD levels and single nucleotide polymorphisms of the VD receptor gene (VDR SNPs) are associated with the efficacy of tenofovir disoproxil fumarate (TDF) in the prevention of MTCT in pregnant women with high HBV viral loads.

Methods

Thirty-eight pregnant women who were at high risk for MTCT of HBV (those with an HBV DNA level ≥ 2 × 10⁵ IU/mL during 12-24 wk of gestation) receiving antiviral therapy of TDF between June 1, 2019 and June 30, 2021 in Mianyang

SUBMITTER: Wang R 

PROVIDER: S-EPMC10237097 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature