Transcriptome-wide identification of altered RNA m⁶A profiles in cardiac tissue of rats with LPS-induced myocardial injury.

ABSTRACT:

Purpose

Myocardial injury is a common complication in patients with endotoxaemia/sepsis, especially in children. Moreover, it develops through an unclear pathophysiological mechanism, and effective therapies are lacking. Recently, RNA modification, particularly N ⁶-methyladenosine (m⁶A) modification, has been found to be involved in various physiological processes and to play important roles in many diseases. However, the role of m⁶A modification in endotoxaemia/sepsis-induced myocardial injury is still in its infancy. Therefore, we attempted to construct the m⁶A modification map of myocardial injury in a rat model treated by lipopolysaccharide (LPS) and explore the role of m⁶A modification in LPS-induced myocardial inju

SUBMITTER: Wang W 

PROVIDER: S-EPMC10237353 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature