Histological and molecular classifications of pediatric glioma with time-dependent diffusion MRI-based microstructural mapping.

ABSTRACT:

Background

Gliomas are the most common type of central nervous system tumors in children, and the combination of histological and molecular classification is essential for prognosis and treatment. Here, we proposed a newly developed microstructural mapping technique based on diffusion-time-dependent diffusion MRI td-dMRI theory to quantify tumor cell properties and tested these microstructural markers in identifying histological grade and molecular alteration of H3K27.

Methods

This prospective study included 69 pediatric glioma patients aged 6.14 ± 3.25 years old, who underwent td-dMRI with pulsed and oscillating gradient diffusion sequences on a 3T scanner. dMRI data acquired at varying tds were fitted into a 2-compartment microstructural model to obtain intracellular fract

SUBMITTER: Zhang H 

PROVIDER: S-EPMC10237431 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature