Causal role of the dorsolateral prefrontal cortex in modulating the balance between Pavlovian and instrumental systems in the punishment domain.

ABSTRACT: Previous literature suggests that a balance between Pavlovian and instrumental decision-making systems is critical for optimal decision-making. Pavlovian bias (i.e., approach toward reward-predictive stimuli and avoid punishment-predictive stimuli) often contrasts with the instrumental response. Although recent neuroimaging studies have identified brain regions that may be related to Pavlovian bias, including the dorsolateral prefrontal cortex (dlPFC), it is unclear whether a causal relationship exists. Therefore, we investigated whether upregulation of the dlPFC using transcranial current direct stimulation (tDCS) would reduce Pavlovian bias. In this double-blind study, participants were assigned to the anodal or the sham group; they received stimulation over the right dlPFC for 3 success

SUBMITTER: Kim H 

PROVIDER: S-EPMC10237433 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature