Pan-cancer analysis of the intervertebral-disc-degeneration-related innate immunity gene NAIP.

ABSTRACT:

Background

Intervertebral disc degeneration (IDD) is a progressive chronic condition that commonly causes low back pain. Cancer is among the primary reasons for deaths worldwide. Our purpose was to identify the characteristic genes of IDD and explore the potential association between IDD and cancer.

Methods

Immune cell infiltration and differentially expressed analysis were conducted utilizing data from the GSE124272 database. Enrichment analysis of differentially expressed genes (DEGs) was performed to explore the possible mechanisms underlying IDD development. Moreover, weighted gene correlation network analysis (WGCNA) was applied to select IDD-related hub genes. The immune-related key genes were determined by intersecting DEGs, IDD-related hub genes, and immune genes. Su

SUBMITTER: Xu WB 

PROVIDER: S-EPMC10237447 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature