Senescent immune cells accumulation promotes brown adipose tissue dysfunction during aging.

ABSTRACT: Brown adipose tissue (BAT)-mediated thermogenesis declines with age. However, the underlying mechanism remains unclear. Here we reveal that bone marrow-derived pro-inflammatory and senescent S100A8⁺ immune cells, mainly T cells and neutrophils, invade the BAT of male rats and mice during aging. These S100A8⁺ immune cells, coupled with adipocytes and sympathetic nerves, compromise axonal networks. Mechanistically, these senescent immune cells secrete abundant S100A8 to inhibit adipose RNA-binding motif protein 3 expression. This downregulation results in the dysregulation of axon guidance-related genes, leading to impaired sympathetic innervation and thermogenic function. Xenotransplantation experiments show that human S100A8⁺ immune cells infiltrate mice BA

SUBMITTER: Feng X 

PROVIDER: S-EPMC10237528 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature