Effective immuno-therapeutic treatment of Canine Leishmaniasis.

ABSTRACT:

Background

Canine Leishmaniasis (CanL) caused by the L. infantum species is one of the biggest threats to the health of the South American canine population. Chemotherapeutics currently used for the treatment of CanL fail to induce a total parasite clearance while inducing numerous side effects. As CanL is an immunomodulated disease, the use of immuno-treatments should strengthen the deficient immune response of infected dogs. In this study, we evaluated a nasally administered immunotherapy in dogs naturally infected with L. infantum (stage 2), with both visceral and cutaneous manifestations. Noteworthy, some of them were also infected by other parasites (E. canis, D. immitis, A. platys), what worsen their chance of survival.

Methodology/principal findings

The treatment was

SUBMITTER: Ramos RAN 

PROVIDER: S-EPMC10237639 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature