Fast and versatile sequence-independent protein docking for nanomaterials design using RPXDock.

ABSTRACT: Computationally designed multi-subunit assemblies have shown considerable promise for a variety of applications, including a new generation of potent vaccines. One of the major routes to such materials is rigid body sequence-independent docking of cyclic oligomers into architectures with point group or lattice symmetries. Current methods for docking and designing such assemblies are tailored to specific classes of symmetry and are difficult to modify for novel applications. Here we describe RPXDock, a fast, flexible, and modular software package for sequence-independent rigid-body protein docking across a wide range of symmetric architectures that is easily customizable for further development. RPXDock uses an efficient hierarchical search and a residue-pair transform (RPX) scoring method

SUBMITTER: Sheffler W 

PROVIDER: S-EPMC10237659 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature