Association of gamma-glutamyl transferase variability with risk of osteoporotic fractures: A nationwide cohort study.

ABSTRACT:

Objectives

Gamma-glutamyl transferase (GGT) is related to inflammation, osteoporosis, and vascular diseases. Recently, changes in metabolic parameters have been proposed as osteoporosis biomarkers. We aimed to assess longitudinally the association of GGT variability with osteoporotic fractures.

Methods

From the National Health Insurance Service-Health Screening Cohort database, participants who underwent three or more health examinations between 2003 and 2008 were included (n = 1,072,432). Variability indexes were as follows: (1) coefficient of variation (CV), (2) standard deviation (SD), and (3) variability independent of the mean (VIM). The primary outcome was occurrence of osteoporotic fracture, defined as identification of one of the following international classificatio

SUBMITTER: Kim D 

PROVIDER: S-EPMC10237661 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature