Shared enhancer gene regulatory networks between wound and oncogenic programs.

ABSTRACT: Wound response programs are often activated during neoplastic growth in tumors. In both wound repair and tumor growth, cells respond to acute stress and balance the activation of multiple programs, including apoptosis, proliferation, and cell migration. Central to those responses are the activation of the JNK/MAPK and JAK/STAT signaling pathways. Yet, to what extent these signaling cascades interact at the cis-regulatory level and how they orchestrate different regulatory and phenotypic responses is still unclear. Here, we aim to characterize the regulatory states that emerge and cooperate in the wound response, using the Drosophila melanogaster wing disc as a model system, and compare these with cancer cell states induced by ras^V12scrib

SUBMITTER: Floc'hlay S 

PROVIDER: S-EPMC10238094 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature