Endothelium and Subendothelial Matrix Mechanics Modulate Cancer Cell Transendothelial Migration.

ABSTRACT: Cancer cell extravasation, a key step in the metastatic cascade, involves cancer cell arrest on the endothelium, transendothelial migration (TEM), followed by the invasion into the subendothelial extracellular matrix (ECM) of distant tissues. While cancer research has mostly focused on the biomechanical interactions between tumor cells (TCs) and ECM, particularly at the primary tumor site, very little is known about the mechanical properties of endothelial cells and the subendothelial ECM and how they contribute to the extravasation process. Here, an integrated experimental and theoretical framework is developed to investigate the mechanical crosstalk between TCs, endothelium and subendothelial ECM during in vitro cancer cell extravasation. It is found that cancer cell actin-rich protrusio

SUBMITTER: Javanmardi Y 

PROVIDER: S-EPMC10238207 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature