Serum uric acid and diabetic peripheral neuropathy: a double-edged sword.

ABSTRACT:

Background and objectives

Research suggests that diabetic peripheral neuropathy (DPN) is related to high serum uric acid (SUA) level, although its correlation with low SUA level has not been reported. Here, diabetic patients with hyperuricemia were excluded, and the correlation between low SUA level and DPN was explored.

Subjects and methods

This prospective observational clinical study enrolled 525 type 2 diabetes mellitus (T2DM) patients without hyperuricemia, who were divided into the diabetes with symptomatic neuropathy (150 cases), diabetes with asymptomatic neuropathy (125 cases) and diabetes with no neuropathy (250 cases) groups.

Results

The SUA slightly decreased in subjects with asymptomatic DPN compared with those with no neuropathy and greatly decreased in

SUBMITTER: Zhuang Y 

PROVIDER: S-EPMC10238292 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature