Nanoparticle pre-treatment for enhancing the survival and activation of pulmonary macrophage transplant.

ABSTRACT: Despite recent clinical successes of chimeric antigen receptor T cell therapies in treating liquid cancers, many lingering challenges stand in the way of therapeutic translation to broader types of malignancies. Macrophages have been proposed as alternatives to T cells given macrophages' advantages in promoting tumor infiltration, acquiring diverse antigens, and possessing the ability to continuously stimulate adaptive responses. However, the poor survival of macrophages upon transplantation in addition to transient anti-tumor phenotypical states have been major obstacles standing in the way of macrophage-based cell therapies. Given recent discoveries of nanoparticle strategies in improving macrophage survival and promoting phenotype retention, we herein report the ability to extend the su

SUBMITTER: Jarai BM 

PROVIDER: S-EPMC10238309 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature