Adaptive responses of yeast strains tolerant to acidic pH, acetate, and supraoptimal temperature.

ABSTRACT: Ethanol fermentations can be prematurely halted as Saccharomyces cerevisiae faces adverse conditions, such as acidic pH, presence of acetic acid, and supraoptimal temperatures. The knowledge on yeast responses to these conditions is essential to endowing a tolerant phenotype to another strain by targeted genetic manipulation. In this study, physiological and whole-genome analyses were conducted to obtain insights on molecular responses which potentially render yeast tolerant towards thermoacidic conditions. To this end, we used thermotolerant TTY23, acid tolerant AT22, and thermo-acid tolerant TAT12 strains previously generated by adaptive laboratory evolution (ALE) experiments. The results showed an increase in thermoacidic profiles in the tolerant strains. The whole-genome sequence revea

SUBMITTER: Salas-Navarrete PC 

PROVIDER: S-EPMC10238323 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature