Portable and integrated microfluidic flow control system using off-the-shelf components towards organs-on-chip applications.

ABSTRACT: Organ-on-a-chip (OoC) devices require the precise control of various media. This is mostly done using several fluid control components, which are much larger than the typical OoC device and connected through fluidic tubing, i.e., the fluidic system is not integrated, which inhibits the system's portability. Here, we explore the limits of fluidic system integration using off-the-shelf fluidic control components. A flow control configuration is proposed that uses a vacuum to generate a fluctuation-free flow and minimizes the number of components used in the system. 3D printing is used to fabricate a custom-designed platform box for mounting the chosen smallest footprint components. It provides flexibility in arranging the various components to create experiment-specific systems. A demonstrat

SUBMITTER: Zhu H 

PROVIDER: S-EPMC10238329 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature