Lipid nanoparticles for gene therapy in ocular diseases.

ABSTRACT:

Objectives

Lipid nanoparticles, as a nucleic acid delivery system, have been used as an alternative to treat ocular diseases, since they can cross the ocular barrier and efficiently transfecting nucleic acids to various cells of the eye. The size influences the transfection of genes, biological distribution, diffusion, and cellular uptake. It is therefore important to establish a relationship between size, formulation, and encapsulation percentage.

Evidence acquisition

In this review, we used a search strategy to compare studies of nanomedicine systems aimed at eye diseases where the size of the nanoparticles and the efficiency of encapsulation of genetic material are reported based on the criteria of Preferred Reporting Items for Systematic Reviews (PRISMA ScR 2020 guidelin

SUBMITTER: Chapa Gonzalez C 

PROVIDER: S-EPMC10238339 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature