Mannose-modified hyaluronic acid nanocapsules for the targeting of tumor-associated macrophages.

ABSTRACT: Tumor-associated macrophages (TAMs), a class of immune cells that play a key role in tumor immunosuppression, are recognized as important targets to improve cancer prognosis and treatment. Consequently, the engineering of drug delivery nanocarriers that can reach TAMs has acquired special relevance. This work describes the development and biological evaluation of a panel of hyaluronic acid (HA) nanocapsules (NCs), with different compositions and prepared by different techniques, designed to target macrophages. The results showed that plain HA NCs did not significantly influence the polarization of M0 and M2-like macrophages towards an M1-like pro-inflammatory phenotype; however, the chemical functionalization of HA with mannose (HA-Man) led to a significant increase of NCs uptake by M2 mac

SUBMITTER: Fernandez-Marino I 

PROVIDER: S-EPMC10238357 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature