Eradicating the tumor "seeds": nanomedicines-based therapies against cancer stem cells.

ABSTRACT:

Objectives

Cancer stem cells (CSCs), a small subpopulation of cells with high tumorigenesis and strong intrinsic drug resistance, exhibit self-renewal and differentiation abilities. CSCs play a crucial role in tumor progression, drug resistance, recurrence and metastasis,and conventional therapy is not enough to eradicate them. Therefore, developing novel therapies targeting CSCs to increase drug sensitivity and preventing relapse is essential. The objective of this review is to present nanotherapies that target and eradicate the tumor "seeds".

Evidence acquisition

Evidence was collected and sorted from the literature ranging from 2000 to 2022, using appropriate keywords and key phrases as search terms within scientific databases such as Web of Science, PubMed and Google Sch

SUBMITTER: Li L 

PROVIDER: S-EPMC10238364 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature