Microstructural and functional plasticity following repeated brain stimulation during cognitive training in older adults.

ABSTRACT: The combination of repeated behavioral training with transcranial direct current stimulation (tDCS) holds promise to exert beneficial effects on brain function beyond the trained task. However, little is known about the underlying mechanisms. We performed a monocenter, single-blind randomized, placebo-controlled trial comparing cognitive training to concurrent anodal tDCS (target intervention) with cognitive training to concurrent sham tDCS (control intervention), registered at ClinicalTrial.gov (Identifier NCT03838211). The primary outcome (performance in trained task) and secondary behavioral outcomes (performance on transfer tasks) were reported elsewhere. Here, underlying mechanisms were addressed by pre-specified analyses of multimodal magnetic resonance imaging before and after a thr

SUBMITTER: Antonenko D 

PROVIDER: S-EPMC10238397 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature