M1BP is an essential transcriptional activator of oxidative metabolism during Drosophila development.

ABSTRACT: Oxidative metabolism is the predominant energy source for aerobic muscle contraction in adult animals. How the cellular and molecular components that support aerobic muscle physiology are put in place during development through their transcriptional regulation is not well understood. Using the Drosophila flight muscle model, we show that the formation of mitochondria cristae harbouring the respiratory chain is concomitant with a large-scale transcriptional upregulation of genes linked with oxidative phosphorylation (OXPHOS) during specific stages of flight muscle development. We further demonstrate using high-resolution imaging, transcriptomic and biochemical analyses that Motif-1-binding protein (M1BP) transcriptionally regulates the expression of genes encoding critical components for OX

SUBMITTER: Poliacikova G 

PROVIDER: S-EPMC10238438 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature