Impact of TAVR on coronary artery hemodynamics using clinical measurements and image-based patient-specific in silico modeling.

ABSTRACT: In recent years, transcatheter aortic valve replacement (TAVR) has become the leading method for treating aortic stenosis. While the procedure has improved dramatically in the past decade, there are still uncertainties about the impact of TAVR on coronary blood flow. Recent research has indicated that negative coronary events after TAVR may be partially driven by impaired coronary blood flow dynamics. Furthermore, the current technologies to rapidly obtain non-invasive coronary blood flow data are relatively limited. Herein, we present a lumped parameter computational model to simulate coronary blood flow in the main arteries as well as a series of cardiovascular hemodynamic metrics. The model was designed to only use a few inputs parameters from echocardiography, computed tomography and a

SUBMITTER: Garber L 

PROVIDER: S-EPMC10238523 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature