Implication of chromosomal microarray analysis prior to in-utero repair of fetal open neural tube defect.

ABSTRACT:

Objective

In-utero repair of open neural tube defects (ONTD) is an accepted treatment option with demonstrated superior outcome for eligible patients. While current guidelines recommend genetic testing by chromosomal microarray analysis (CMA) when a major congenital anomaly is detected prenatally, the requirement for an in-utero repair, based on the Management of Myelomeningocele Study (MOMS) criteria, is a normal karyotype. In this study, we aimed to evaluate if CMA should be recommended as a prerequisite for in-utero ONTD repair.

Methods

This was a retrospective cohort study of pregnancies complicated by ONTD that underwent laparotomy-assisted fetoscopic repair or open-hysterotomy fetal surgery at a single tertiary center between September 2011 and July 2021. All patients

SUBMITTER: Zemet R 

PROVIDER: S-EPMC10238557 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature