Extracellular vesicle-based biovectors in chronic wound healing: Biogenesis and delivery approaches.

ABSTRACT: Chronic wounds remain an unresolved medical issue because of major social and therapeutic repercussions that require extensive focus. Recent related theragnostic focuses only on wound management and is not effectively promoting chronic wound healing. The rising number of patients with either under-healing or over-healing wounds highlights the ineffectiveness of current wound-healing treatments, and thus, there is an unmet need to focus on alternative treatments. To cover this gap, extracellular vesicles (EVs), for targeted delivery of therapeutics, are emerging as a potential therapy to treat both acute and persistent wounds. To address these issues, we explore the core biology of EVs, associated pharmacology, comprehension of immunogenic outcomes, and potential for long-term wound treatme

SUBMITTER: Garima 

PROVIDER: S-EPMC10238601 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature