Homocysteine levels, H-Hypertension, and the MTHFR C677T genotypes: A complex interaction.

ABSTRACT:

Background and objectives

High homocysteine levels are associated with increased risk of hypertension and stroke. Homocysteine is metabolized by the methylenetetrahydrofolate reductase (MTHFR). We aimed to investigate the levels of homocysteine and their association with hypertension, stroke, and antihypertensive medication usage in patients with different MTHFR C677T genotypes.

Methods and results

Genotype frequency of MTHFR polymorphism was performed, and plasma homocysteine levels were measured in 2,640 adult Lebanese patients. Hypertension, history of stroke, and list of medications were documented, among other clinical and demographic parameters. The TT mutant genotype and the T mutant allele of MTHFR were more prevalent in hyperhomocysteinem

SUBMITTER: Al Hageh C 

PROVIDER: S-EPMC10238895 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature