Characterization of Hofbauer cell polarization and VEGF localization in human term placenta from active and inactive pregnant individuals.

ABSTRACT: Physical activity (PA) during pregnancy is associated with parental and fetal health benefits; however, the mechanisms through which these benefits arise are yet to be fully understood. In healthy pregnancies Hofbauer cells (HBCs) comprise a heterogenous population containing CD206⁺ and CD206^- phenotypes. In healthy pregnancies, CD206⁺ represent the majority, while dysregulations have been associated with pathological conditions. HBCs have also been identified as potential drivers of angiogenesis. As PA induces changes in macrophage polarization in non-pregnant populations, this novel study examined the relationship between PA and HBC polarization and to identify which HBC phenotypes express VEGF. Participants were classified as active or inactive, and immu

SUBMITTER: Goudreau AD 

PROVIDER: S-EPMC10238919 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature