Fertility decline in female mosquitoes is regulated by the <i>orco</i> olfactory co-receptor.

ABSTRACT: Female Aedes aegypti mosquitoes undergo multiple rounds of reproduction, known as gonotrophic cycles. These cycles span the period from blood meal intake to oviposition. Understanding how reproductive success is maintained across gonotrophic cycles allows for the identification of molecular targets to reduce mosquito population growth. Odorant receptor co-receptor (orco) encodes a conserved insect-specific transmembrane ion channel that complexes with tuning odorant receptors (ORs) to form a functional olfactory receptor. orco expression has been identified in the male and female mosquito germline, but its role is unclear. We report an orco-dependent, maternal effect reduction in fertility after the first gonotrophic cycle. This phenotype was removed by CRISPR-C

SUBMITTER: David OG 

PROVIDER: S-EPMC10239028 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature