Kremen2 drives the progression of non-small cell lung cancer by preventing SOCS3-mediated degradation of EGFR.

ABSTRACT:

Background

The transmembrane receptor Kremen2 has been reported to participate in the tumorigenesis and metastasis of gastric cancer. However, the role of Kremen2 in non-small cell lung cancer (NSCLC) and the underlying mechanism remain unclear. This study aimed to explore the biological function and regulatory mechanism of Kremen2 in NSCLC.

Methods

The correlation between Kremen2 expression and NSCLC was assessed by analyzing the public database and clinical tissue samples. Colony formation and EdU assays were performed to examine cell proliferation. Transwell and wound healing assays were used to observe cell migration ability. Tumor-bearing nude mice and metastatic tumor models were used to detect the in vivo tumorigenic and metastatic abilities of the NSCLC cells. An imm

SUBMITTER: Sun Y 

PROVIDER: S-EPMC10239115 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature