CXCR2 expression during melanoma tumorigenesis controls transcriptional programs that facilitate tumor growth.

ABSTRACT:

Background

Though the CXCR2 chemokine receptor is known to play a key role in cancer growth and response to therapy, a direct link between expression of CXCR2 in tumor progenitor cells during induction of tumorigenesis has not been established.

Methods

To characterize the role of CXCR2 during melanoma tumorigenesis, we generated tamoxifen-inducible tyrosinase-promoter driven Braf^V600E/Pten^-/-/Cxcr2^-/- and NRas^Q61R/INK4a^-/-/Cxcr2^-/- melanoma models. In addition, the effects of a CXCR1/CXCR2 antagonist, SX-682, on melanoma tumorigenesis were evaluated in Braf^V600E/Pten^-/- and NRas^Q61R/INK4a^-/- mice and in melanoma cell lines. Potential mechanisms by which Cxcr2 affects

SUBMITTER: Yang J 

PROVIDER: S-EPMC10239119 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature