High HSPB1 expression predicts poor clinical outcomes and correlates with breast cancer metastasis.

ABSTRACT:

Background

Heat shock protein beta-1 (HSPB1) is a crucial biomarker for pathological processes in various cancers. However, the clinical value and function of HSPB1 in breast cancer has not been extensively explored. Therefore, we adopted a systematic and comprehensive approach to investigate the correlation between HSPB1 expression and clinicopathological features of breast cancer, as well as determine its prognostic value. We also examined the effects of HSPB1 on cell proliferation, invasion, apoptosis, and metastasis.

Methods

We investigated the expression of HSPB1 in patients with breast cancer using The Cancer Genome Atlas and immunohistochemistry. Chi-squared test and Wilcoxon signed-rank test were used to examine the relationship between HSPB1 expression and clinicopa

SUBMITTER: Huo Q 

PROVIDER: S-EPMC10239126 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature