Gene coexpression network during ontogeny in the yellow fever mosquito, Aedes aegypti.

ABSTRACT:

Background

The behaviors and ontogeny of Aedes aegypti are closely related to the spread of diseases caused by dengue (DENV), chikungunya (CHIKV), Zika (ZIKV), and yellow fever (YFV) viruses. During the life cycle, Ae. aegypti undergoes drastic morphological, metabolic, and functional changes triggered by gene regulation and other molecular mechanisms. Some essential regulatory factors that regulate insect ontogeny have been revealed in other species, but their roles are still poorly investigated in the mosquito.

Results

Our study identified 6 gene modules and their intramodular hub genes that were highly associated with the ontogeny of Ae. aegypti in the constructed network. Those modules were found to be enriched in functional roles related to cuticle development, ATP gene

SUBMITTER: Lin Z 

PROVIDER: S-EPMC10239134 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature