Genomic approaches to identify and investigate genes associated with atrial fibrillation and heart failure susceptibility.

ABSTRACT: Atrial fibrillation (AF) and heart failure (HF) contribute to about 45% of all cardiovascular disease (CVD) deaths in the USA and around the globe. Due to the complex nature, progression, inherent genetic makeup, and heterogeneity of CVDs, personalized treatments are believed to be critical. To improve the deciphering of CVD mechanisms, we need to deeply investigate well-known and identify novel genes that are responsible for CVD development. With the advancements in sequencing technologies, genomic data have been generated at an unprecedented pace to foster translational research. Correct application of bioinformatics using genomic data holds the potential to reveal the genetic underpinnings of various health conditions. It can help in the identification of causal variants for AF, HF, and

SUBMITTER: Patel KK 

PROVIDER: S-EPMC10239148 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature