3D-printed hydrogel particles containing PRP laden with TDSCs promote tendon repair in a rat model of tendinopathy.
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ABSTRACT:
SUBMITTER: Li C
PROVIDER: S-EPMC10239155 | biostudies-literature | 2023 Jun
REPOSITORIES: biostudies-literature
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3D-printed hydrogel particles containing PRP laden with TDSCs promote tendon repair in a rat model of tendinopathy.
Li Congsun C Wang Jie J Yang Weinan W Yu Kang K Hong Jianqiao J Ji Xiaoxiao X Yao Minjun M Li Sihao S Lu Jinwei J Chen Yazhou Y Yan Shigui S Wu Haobo H Ma Chiyuan C Yu Xiaohua X Jiang Guangyao G Liu An A
Journal of nanobiotechnology 20230603 1
Long-term chronic inflammation after Achilles tendon injury is critical for tendinopathy. Platelet-rich plasma (PRP) injection, which is a common method for treating tendinopathy, has positive effects on tendon repair. In addition, tendon-derived stem cells (TDSCs), which are stem cells located in tendons, play a major role in maintaining tissue homeostasis and postinjury repair. In this study, injectable gelatine methacryloyl (GelMA) microparticles containing PRP laden with TDSCs (PRP-TDSC-GM) ...[more]
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