Epigenetic age acceleration mediates the association between smoking and diabetes-related outcomes.

ABSTRACT:

Background

Smoking can lead to the deterioration of lung function and susceptibility to diabetes. Recently, smoking was found to induce DNA methylation (DNAm) changes in some cytosine-phosphate-guanine sites (CpGs). As linear combinations of DNAm levels of aging-related CpGs, five measures of epigenetic age acceleration (EAA) have received extensive attention: HannumEAA, IEAA, PhenoEAA, GrimEAA, and DunedinPACE. It is of interest to explore whether some measures of EAA can mediate the associations of smoking with diabetes-related outcomes and indices of ventilatory lung function.

Methods and results

In this study, we included self-reported smoking variables (smoking status, the number of pack-years, and years since smoking cessation), seven DNAm markers (HannumEAA, IEAA, Phe

SUBMITTER: Chang XY 

PROVIDER: S-EPMC10239178 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature