Extrachromosomal Amplification of Human Papillomavirus Episomes Is a Mechanism of Cervical Carcinogenesis.

ABSTRACT:

Significance

Multimers of the HPV genome are generated in cervical tumors replicating as extrachromosomal episomes, which is associated with deletion and rearrangement of the HPV genome and provides a mechanism for oncogenesis without integration.

SUBMITTER: Rossi NM 

PROVIDER: S-EPMC10239328 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature