Activation Profile of TAS2R2, the 26th Human Bitter Taste Receptor.

ABSTRACT:

Scope

To avoid ingestion of potentially harmful substances, humans are equipped with about 25 bitter taste receptor genes (TAS2R) expressed in oral taste cells. Humans exhibit considerable variance in their bitter tasting abilities, which are associated with genetic polymorphisms in bitter taste receptor genes. One of these variant receptor genes, TAS2R2, is initially believed to represent a pseudogene. However, TAS2R2 exists in a putative functional variant within some populations and can therefore be considered as an additional functional bitter taste receptor.

Methods and results

To learn more about the function of the experimentally neglected TAS2R2, a functional screening with 122 bitter compounds is performed. The study observes responses with eight of the 122 bitter s

SUBMITTER: Lang T 

PROVIDER: S-EPMC10239339 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature