Oligonucleotide nanoassemblies with allyl bromide scaffold-based small molecules.

ABSTRACT: The development of oligonucleotide nanoassemblies with small molecules has shown great potential in bio-medical applications. However, the interaction of negatively charged oligonucleotides with halogenated small molecules represents a scientific challenge. Here, we introduced a distinct allyl bromide halogenated scaffold, which exhibits specific interaction with adenine nucleic bases of the oligonucleotides, thus leading to the formation of self-assembled nanostructures.

SUBMITTER: Abbas SJ 

PROVIDER: S-EPMC10239407 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature