The value of platelet-rich plasma in women with previous implantation failure: a systematic review and meta-analysis.

ABSTRACT:

Objective

To assess the value of intrauterine PRP to improve IVF outcome in women with previous implantation failure.

Methods

Screening of Pubmed, Web of Science, and other databases from inception to August 2022 using the keywords related to "platelet-rich plasma" OR "PRP" AND "IVF" "implantation failure." Twenty-nine studies (3308 participants) were included in our analysis, 13 were RCTs, 6 were prospective cohorts, 4 were prospective single arm, and 6 were retrospective analyses. Extracted data included settings of the study, study type, sample size, participants' characteristics, route, volume, timing of PRP administration, and outcome parameters.

Results

Implantation rate was reported in 6 RCTs (886 participants) and 4 non-RCTs (732 participants). The odds ratio

SUBMITTER: Maged AM 

PROVIDER: S-EPMC10239431 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature