METTL3-dependent m⁶A methylation facilitates uterine receptivity and female fertility via balancing estrogen and progesterone signaling.

ABSTRACT: Infertility is a worldwide reproductive health problem and there are still many unknown etiologies of infertility. In recent years, increasing evidence emerged and confirmed that epigenetic regulation played a leading role in reproduction. However, the function of m⁶A modification in infertility remains unknown. Here we report that METTL3-dependent m⁶A methylation plays an essential role in female fertility via balancing the estrogen and progesterone signaling. Analysis of GEO datasets reveal a significant downregulation of METTL3 expression in the uterus of infertile women with endometriosis or recurrent implantation failure. Conditional deletion of Mettl3 in female reproductive tract by using a Pgr-Cre driver results in infertility due to compromised uterine endomet

SUBMITTER: Wan S 

PROVIDER: S-EPMC10239469 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature