CFP1 governs uterine epigenetic landscapes to intervene in progesterone responses for uterine physiology and suppression of endometriosis.

ABSTRACT: Progesterone (P₄) is required for the preparation of the endometrium for a successful pregnancy. P₄ resistance is a leading cause of the pathogenesis of endometrial disorders like endometriosis, often leading to infertility; however, the underlying epigenetic cause remains unclear. Here we demonstrate that CFP1, a regulator of H3K4me3, is required for maintaining epigenetic landscapes of P₄-progesterone receptor (PGR) signaling networks in the mouse uterus. Cfp1^f/f;Pgr-Cre (Cfp1^d/d) mice showed impaired P₄ responses, leading to complete failure of embryo implantation. mRNA and chromatin immunoprecipitation sequencing analyses showed that CFP1 regulates uterine mRNA profiles not only in H3K4me3-dependent but also in H3K4me3-i

SUBMITTER: Yang SC 

PROVIDER: S-EPMC10239508 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature