Yijung-tang improves thermogenesis and reduces inflammation associated with gut microbiota in hypothyroid rats.

ABSTRACT: Currently, considerable attention is focused on exploring the potential relationship between herbal medicine (HM) and the gut microbiome in terms of thermoregulation, which is an important aspect of human health, in modern system biology. However, our knowledge of the mechanisms of HM in thermoregulation is inadequate. Here, we demonstrate that the canonical herbal formula, Yijung-tang (YJT), protects against hypothermia, hyperinflammation, and intestinal microbiota dysbiosis in PTU-induced hypothyroid rats. Notably, these properties were associated with alterations in the gut microbiota and signaling crosstalk between the thermoregulatory and inflammatory mediators in the small intestine and brown adipose tissue (BAT). In contrast to the conventional drug L-thyroxine for curing hypothyroi

SUBMITTER: Khakisahneh S 

PROVIDER: S-EPMC10239510 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature