Differential molecular pathway expression according to chemotherapeutic response in ovarian clear cell carcinoma.

ABSTRACT:

Objective

Ovarian clear cell carcinoma (OCCC) is a distinct entity from epithelial ovarian cancer. The prognosis of advanced and recurrent disease is very poor due to resistance to chemotherapeutic agents. Our aim was to explore the molecular alterations among OCCC patients with different chemotherapeutic responses and to obtain insights into potential biomarkers.

Methods

Twenty-four OCCC patients were included in this study. The patients were divided into two groups based on the relapse time after the first-line platinum-based chemotherapy: the platinum-sensitive group (PS) and the platinum-resistant group (PR). Gene expression profiling was performed using NanoString nCounter PanCancer Pathways Panel.

Results

Gene expression analysis comparing PR vs. PS identified 3

SUBMITTER: Yin M 

PROVIDER: S-EPMC10239578 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature