Declining incidence rate of tuberculosis among close contacts in five years post-exposure: a systematic review and meta-analysis.

ABSTRACT:

Background

Individuals in close contact with active pulmonary tuberculosis (TB) patients showed a high risk of recent infection and, once infected, higher risk of developing active TB in the following years post-exposure. But the peak time of active disease onset is unclear. This study aims to estimate post exposure TB incidence risk among close contacts to provide reference for clinical and public health strategies.

Methods

We searched PubMed, Web of Science, and EMBASE for articles published until December 1, 2022. The incidence rates were quantitatively summarized by means of meta-analysis using the random-effect model.

Results

Of the 5616 studies, 31 studies included in our analysis. For baseline close contacts results, the summarized prevalence of Mycobacterium t

SUBMITTER: Du Y 

PROVIDER: S-EPMC10239604 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature